陈麒先博士，开云平台首页 生物工程学院研究员、博士生导师、国家高层次人才工程入选者、辽宁省"兴辽英才计划"青年拔尖人才、开云平台首页 "星海青年千人"、大连市"青年科技之星"。师从美国工程院院士、日本东京大学 Prof. Kazunori Kataoka（片冈一则教授），曾担任美国麻省理工学院（MIT）化学系（Prof. Jeremiah A. Johnson 研究室）博士后研究员，致力于化学、生物、医学交叉学科研究工作，同时担任麻省理工学院癌症研究中心（MIT Koch Institute）、哈佛大学附属医院麻省总医院（MGH）研究员，从事临床转化工作。陈麒先博士在纳米医学领域，尤其在开发基因和药物递送技术治疗顽固性癌症以及中枢神经疾病取得了突出的进展。迄今在国际著名学术期刊 Nature Nanotechnology、Nature Chemistry、Nature Communications、ACS Central Science、ACS Nano、Chemistry of Materials、Chemical Science、Biomaterials、Bioactive Materials、Small、Journal of Controlled Release、Molecular Therapy 等发表论文100余篇，其中50余篇为第一作者或通讯作者，被他人引用5000余次。

第一作者或通讯作者：

1. S. Zeng, C. Chen, L. Zhang, X. Liu, M. Qian, H. Cui, J. Wang^*, Q. Chen^*, X. Peng. Activation of pyroptosis by organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor cancer immunotherapy.Bioactive Materials, 2022.(IF: 16.874)

2. Q. Chen, K. Osada^*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka^*. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.Biomaterials, 33, 18, 4722, 2012.(IF: 15.304)

3. Q. Chen, K. Osada^*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka^*. Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting.Biomaterials, 113, 253, 2016.(IF: 15.304)

4. Z. Ge^#, Q. Chen^#, K. Osada^*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka^*. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.Biomaterials, 35, 10, 3416, 2014.(IF: 15.304)

5. Q. Chen^#,*, R. Qi^#, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong^*. A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors.Molecular Therapy, 25(1), 92, 2017.(IF: 12.910)

6. H. Cui, Y. Wang, L. Chen, M. Qian, L. Zhang, X. Zheng, X. Yang, L. Chen, Y. Zhao^*, Q. Chen^*, J. Wang^*. Chemotherapeutic potency drastically stimulated by SNAI1-knockdown based on multifaceted nanomedicine.Journal of Controlled Release, 337, 343-355, 2021.(IF: 11.407)

7. J. Xia, M. Qian, Q. Yao, Z. Meng, H. Cui, L. Zhang, Y. Li, S. Wu, J. Wang^*, Q. Chen^*, X. Peng. Synthetic infrared photosensitizer with multi-level targeting functions for precision photodynamic therapy.Journal of Controlled Release, 334, 263-274, 2021.(IF: 11.407)

8. J. Li^#, Q. Chen^#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka^*, Z. Ge^*. Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery.Journal of Controlled Release, 209, 77, 2015.(IF: 11.407)

9. Y. Wang, X. Zheng, J. Liu, Q. Chen^*, Y. Zhao^*. Convergent arrangement of sgRNA and Cas9 into CRISPRsome for transcellular trafficking.ACS Materials Letters, 4, 505-510, 2022.(IF: 11.170)

10. T. Hao^#, Q. Chen^#, Y. Qi, P. Sun, D. Chen, W. Jiang, K. Liu, H. Sun, L. Li, J. Ding^*, Z. Li^*. Biomineralized Gd₂O₃@HSA nanoparticles as a versatile platform for dual-modal imaging and chemo-phototherapy-synergized tumor ablation.Advanced Healthcare Materials, 8, 1901005-1901015, 2019.(IF: 11.092)

11. S. Chen^#, Q. Chen^#, Q. Li, J. An, P. Sun, J. Ma, H. Gao^*. Biodegradable synthetic antimicrobial with aggregation induced emissive luminogens for temporal antibacterial activity and facile bacteria detection.Chemistry of Materials, 30, 1782, 2018.(IF: 10.508)

12. L. Zhang, M. Qian, H. Cui, J. Xia, S. Zeng, J. Wang^*, Qixian Chen^*. Spatiotemporal concurrent liberation of cytotoxins from dual-prodrug nanomedicine to intracellular gradients for synergistic anti-tumor therapy.ACS Applied Materials & Interfaces, 13(5), 6053-6068, 2021.(IF: 10.383)

13. Q. Chen^#,*, R. Qi^#, X. Chen, H. Xiao, W. Dong^*. Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression.ACS Applied Materials & Interfaces, 8, 24404, 2016.(IF: 10.383)

14. X. Han^#, Q. Chen^#, H. Lu, J. Ma, H. Gao^*. Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative.ACS Applied Materials & Interfaces, 7, 28494, 2015.(IF: 10.383)

15. X. Chen^*, H. Gu, J. Yang, S. Wu, J. Liu, X. Yang, Q. Chen^*. Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles.ACS Applied Materials & Interfaces, 9, 8455-8459, 2017.(IF: 10.383)

16. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen^*, H. Gao^*. Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery.ACS Applied Materials & Interfaces, 7, 23760, 2015.(IF: 10.383)

17. X. Yang, Q. Chen^*, J. Yang, S. Wu, J. Liu, Z. Li, D. Liu, X. Chen, Y. Qiu^*.Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness.ACS Applied Materials & Interfaces, 9(50), 44045-44052, 2017.(IF: 10.383)

18. H. Cui, L, Zhang, S. Zeng, Y. Wang, Z. Li, J. Wang^*, Q. Chen^*. Charge reversible pro-ribonuclease enveloped in virus-like synthetic nanocapsules for systemic treatment of intractable glioma.ACS Applied Materials & Interfaces, 14(27), 30493-30506, 2022.(IF: 10.383)

19. W. Wang^#, S. Wu^#, J Wang, Z. Li, H. Cui, S. Lin, J. Zhu, Q. Chen^*. Superoxide dismutase transcellular shuttle constructed from dendritic MOF and charge reversible protein derivatives.Chemical Science, 10, 4476, 2019.(IF: 9.969)

20. J. Xia, J. Li, Q. Yao, M. Qian, H. Cui, L. Zhang, L. Guo, Y. Li, Q. Chen^*, J. Wang^*, X. Peng. Mitochondria specific oxidative injury by near-infrared energy transfer nanoclusters for amplified photodynamic potency.Journal of Colloid and Interface Science, 557, 45-54, 2019.(IF: 9.965)

21. J. Wang, Y. Xia, H. Liu, J. Xia, M. Qian, L. Zhang, L. Chen, Q. Chen^*. Poly(lactobionamidoethyl methacrylate)-based copolymer with ultrasound-labile motif in manufacture of drug delivery nanoparticulates for augmented efficacy to hepatocellular carcinoma.Journal of Colloid and Interface Science, 551, 1-9, 2019.(IF: 9.965)

22. Y. Wang, X. Zheng, J. Liu, Q. Chen^*, Y. Zhao^*. Virus-like siRNA construct dynamically responsive to sequential microenvironments for potent RNAi.Journal of Colloid and Interface Science, 622, 938-949, 2022.(IF: 9.965)

23. J. Wang, X. Shi, Q. Bo, H. Wang, F. Wei, J. Liu, L. Zhang, Q. Chen^*, X. Sun^*. Synthetic anti-angiogenic genomic therapeutics for treatment of neovascular age-related macular degeneration.Asian Journal of Pharmaceutical Science, 16, 623-632, 2021.(IF: 9.273)

24. J. Wang, H. Wang, P. Sun, H. Cui, X. Yang, Q. Chen^*. Circumvent PEGylation dilemma by implementing matrix metalloproteinase-responsive chemistry for promoted tumor gene therapy.Chinese Chemical Letters, 2021.(IF: 8.455)

25. H. Fu, Y. Huang, H. Lu, J. An, D. Liu, Y. Zhang, Q. Chen^*, H. Gao^*. A theranostic saponin nano-assembly based on FRET of an aggregation induced emission photosensitizer and photon up-conversion nanoparticles.Journal of Materials Chemistry B, 7, 5286-5290, 2019.(IF: 7.571)

26. J. Li, Y. Han, Q. Chen^*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge^*, S. Liu. Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin.Journal of Materials Chemistry B, 2, 13, 1813, 2014.(IF: 7.571)

27. H. Zhu, J. An, C. Pang, S. Chen, W. Li, J. Liu, Q. Chen^*, H. Gao^*. A multifunctional polymeric gene delivery system for circumvent biological barriers.Journal of Materials Chemistry B, 7, 384-392, 2019.(IF: 7.571)

28. Y. Huang^#, Q. Chen^#, H. Lu, J. An, H. Zhu, X. Yan, W. Li, H. Gao^*. Near-infrared AIEgen-functionalized and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert spatiotemporal responsibility for promoted gene delivery.Journal of Materials Chemistry B, 6, 6660-6666, 2018.(IF: 7.571)

29. Y. Li, J. Li, B. Chen, Q. Chen^*, G. Zhang, Z. Ge^*, S. Liu. Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection.Biomacromolecules, 15, 8, 2914, 2014.(IF: 6.978)

30. X. Han^#, Q. Chen^#, W. Lu, G. Wu, J. Ma, H. Gao^*. Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form.Chemical Communications, 52, 3907, 2016.(IF: 6.065)

31. P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu, Q. Chen^*. Transcellular delivery of messenger RNA payloads by cationic supramolecular MOF platform.Chemical Communications, 54, 11304-11307, 2018.(IF: 6.065)

32. D. Liu^#, Q. Chen^#, Y. Long, J. Ma, H. Gao^*. A thermo-responsive polyurethane organogel for norfloxacin delivery.Polymer Chemistry, 9, 228, 2018.(IF: 5.364)

33. S. Chen^#, Q. Chen^#, S. Dong, J. Ma, Y. Yang, L. Chen^*, H. Gao^*. Polymerbrush decorated MOF nanoparticles loaded with AIEgens, anticancer drug, and supramolecular glue for regulating and in situ observing DOX release.Macromolecular Bioscience, 18(12), 1800317, 2018.(IF: 5.859)

34. T. Wang^#, Q. Chen^#, W. Li, G. Wu, J. Ma, H. Gao^*. Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing.Bioconjugate Chemistry, 27, 1949, 2016.(IF: 6.069)

35. J. Xia, J. Wang, X. Wang, M. Qian, L. Zhang, Q. Chen^*.Ultrasound-responsive nanoparticulate for selective amplification of chemotherapeutic potency for ablation of solid tumors.Bioconjugate Chemistry, 29(10), 3467-3475, 2018.(IF: 6.069)

36. Q. Bai, J. Liu, J. Tang, Z. Li, X. Zheng, Q. Chen^*.Redox-responsive polymeric RNAi based on multivalent conjugation of siRNA for improved intracellular delivery.Bioconjugate Chemistry, 30, 11, 2777-2781, 2019.(IF: 6.069)

37. X. Xie, J. Wang, L. Zhang, S. Zeng, X. Su, Q. Chen^*. Bioresorbable depot for sustained release of immunostimulotory resiquimod in suppressing both primary triple-negative breast tumors and metastatic occurrence.Bioconjugate Chemistry, 32(5), 1008-10016, 2021.(IF: 6.069)

38. Z. Jiang, Q. Chen^*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao^*. Polyplex micelle with pH-responsive PEG detachment and functional tetraphenylene incorporation to promote systemic gene expression.Bioconjugate Chemistry, 28 (11), 2849-2858, 2017.(IF: 6.069)

39. C. Zhang, M. Qian, L. Zhang, H. Zheng, M Zhang, Y. Jiao, Y. Kafuti, Q. Chen^*, J. Wang^*. A near-infrared fluorescent probe with ultra-large Stokes shift for the detection of HNO in cells and mice.Journal of Luminescence, 241, 2021.(IF: 4.171)

40. J. Yang^*, X. Wang, R. Liang, R. Kong, Y. Sun, J. Tang, L. Li, L. Xue, Q. Chen^*. Polymorphism, thermal stability and biodegradation of poly(1,4-butylene adipate) manipulated by a benzene-1,3,5-tricarboxamide-based nucleating agent.Journal of Materials Science, 53, 10569-10581, 2018.(IF: 4.682)

41. L. Zhang, M. Qian, J. Wang^*, J. Xia, H. Cui, Q. Chen^*. Nitrophenyl-engaged photocleavage of an amphiphilic copolymer for spatiotemporally controlled drug release.Journal of Materials Science, 54(20), 13298-13313, 2019.(IF: 4.682)

42. J. Yang, R. Liang, Y. Chen^*, C. Zhang, R. Zhang, X. Wang, R. Kang, Q. Chen^*. Using a self-assemblable nucleating agent to tailor crystallization behavior, crystal morphology, polymorphic crystalline structure, and biodegradability of poly(1,4-butylene adipate).Industrial & Engineering Chemistry Research, 56(28), 7910-7919, 2017.(IF: 4.326)

43. Q. Chen, K. Osada^*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka^*. A tadpole-shaped gene carrier with distinct phase segregation in ternary polymeric micelle.Soft Matter, 11, 14, 2718, 2015.(IF: 4.046)

44. H. Cui, J. Xia, L. Zhang, M. Qian, H. Wang, J. Wang^*, Q. Chen^*. Integument of cytoplasmic membrane onto cationic DNA condensates for selective gene expression at homologous cells.ACS Applied Bio Materials, 2, 4537-4544, 2019.

45. L. Zhang, Q. Chen^*, J. Wang^*. Advances in reactive oxygen species responsive antineoplastic prodrugs.Acta Chimica Sinica,78(7), 642-656, 2020.(IF: 2.789)

46. Y. Wang^#, X. Zheng^#, J. Liu, Q. Chen^*, Y. Zhao^*. Tumor-targeted anti-VEGF RNAi capable of sequentially responding to intracellular microenvironments for potent systemic tumor suppression.ACS Applied Bio Materials, 3(12), 9145-9155, 2020.

47. Q. Chen, X. Sui, L. Zhang, Q. Zhang, X. Han, X. Su, H. Cui, M. Qian, S. Zeng, J. Wang^*. Camptothecin nanoprodrug possessing dual-responsiveness to endolysosomal pH and cytosolic redox for amplified cytotoxic potency.ACS Applied Bio Materials, 4(6), 4990-4998, 2021.

48. Y. Wang, S. Zeng, C. Cui, H. Li, J. Wang, Q. Chen. Reversible chemical protein modification to endogenous glutathione and its utilities in the manufacture of transcellular pro-enzymes.Biomacromolecules, 23(5), 2138-2149, 2022.(IF: 6.978)

49. M. Zhang, J. Liu, Y. Jiao, L. Zhang, H. Cui, S. Zeng, H. Li, C. Zhang, J. Lin, X. Wang^*, J. Wang^*, Q. Chen^*. Revascularization by virus-like self-spooling toroidal plasmid condensates for angiogenesis of hindlimb ischemia.ACS Applied Materials & Interfaces, 2022.(IF: 10.383)

50. Y. S. Kafuti, S. Zeng, M. Qian, C. Zhang, X. Liu, J. Wang^*, Q. Chen^*. A novel NIR fluorescent probe with fast response and large stokes shift for the detection and imaging of hypochlorous acid in living cells.Dyes and Pigments, 199, 110067, 2022.(IF: 5.122)

51. Q. Lu, H. Cui, W. Li, T. Liu^*, Q. Chen^*, Q. Yang^*.Synthetic nanoscale RNAi constructs as pesticides for the control of Locust Migratoria.Journal of Agricultural and Food Chemistry, 2022.(IF: 5.895)

52. H. Cui, M. Zhang, L. Zhang, H. Li, Y. Zhao, J. Wang^*, Qixian Chen^*.pH-responsive organic/inorganic hybrid nanocolloids for transcellular delivery of ribonucleolytic payloads toward targeted anti-glioma therapy.Journal of Colloid and Interface Science, 2022.(IF: 9.965)

53.L. Zhang, H. Cui, H. Zheng, X. Yin, J. Lin, Y. Wang, Y. Zhao, H. Li, J. Wang, Q. Chen^*. Simultaneous knockdown of immune suppressive CD47 and PD-L1 by tumor microenvironment-responsive multifaceted prodrug nanomedicine for amplified anti-tumor potencies.Journal of Controlled Release, 2022.(IF: 11.407)

其他共同作者：

54. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka^*. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.Nature Nanotechnology, 6, 12, 815, 2011.(IF: 40.523)

55. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge^*. Self-sufficing H₂O₂-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy.Journal of Controlled Release, 225, 64, 2016.(IF: 11.407)

56. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen^*. Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy.Biomaterials, 100, 118, 2016.(IF: 15.304)

57. R. Qi, Y. Wang, P. Bruno, H. Xiao, Y. Yu, T. Li, S. Lauffer, W. Wei, Q. Chen, X. Kang, H. Song, X. Yang, X. Huang, A. Detappe, U. Matulonis, D. Pépin, M. Hemann, M. Birrer, P. Ghoroghchian^*. Nanoparticle-conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.Nature Communications, 8(1), 2166, 2017.(IF: 17.694)

58. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka^*. Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity.Chemical Communications, 51, 15, 3158, 2015.(IF: 6.065)

59. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka^*. Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivogene transfection with reduced toxicity.Journal of Controlled Release, 155, 2, 296, 2011.(IF: 11.407)

60. H. V.-T. Nguyen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D. Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson^*. Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors.ACS Central Science, 3, 800-811, 2017.(IF: 18.728)

61. K. Itaka, S. Uchida^*, Q. Chen, T. Ishii, K. Osada, K. Kataoka^*. Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses.Human Gene Therapy, 10, 22, 88, 2011.(IF: 4.793)

62. H. Zhang, Z. Lu, S. Wu, X. Chen, Q. Chen, P. Gao, Y Yu, Z. Peng, J. Ye^*. Efficient and controllable growth of vertically oriented graphene nanosheets by mesoplasma chemical vapor deposition.Carbon, 147, 341-347, 2019.(IF: 11.307)

63. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang^*. Fabrication and physical properties of poly(epsilon-caprolactone)/modified graphene nanocomposite.Macromolecular Materials and Engineering, 302(3), 1600328, 2016.(IF: 4.402)

64. Z. Li, Q. Chen, Y. Qi, Z. Liu, T. Hao, X. Sun, M. Qiao, X. Ma, T. Xu, X. Zhao, C. Yang, D. Chen^*.Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-vitamin E Succinate for reversing tumor multidrug resistance.Biomacromolecules, 19, 2595-2609, 2018.(IF: 6.978)

65. B. Liu, H. Zhang, Q. Chen, P. Mi^*. Ligand-installed anti-VEGF genomic nanocarriers for effective suppression of primary tumors and metastasis.Journal of Controlled Release, 320, 314-327, 2020.(IF: 11.407)

66. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka^*. Single-stranded DNA-packaged polyplex micelle as AVV-inspired compacted gene vector to systemically target stroma-rich pancreatic cancer.ACS Nano, 13,12732-12742, 2019.(IF: 18.027)

67. X. Yan, Q. Chen, J. An. D. Liu, Y. Huang, R. Yang, W. Li, L. Chen, H. Gao^*. Hyaluronic acid/PEGylated amphiphilic nanoparticulates for pursuit of selective intracellular doxorubicin release.Journal of Materials Chemistry B, 7, 95-102, 2019.(IF: 7.571)

68. Y. Xia, J. Xia, H. Cui, M. Qian, L. Zhang, Q. Chen, J. Wang^*. Homologous cell membrane coated smart drug release nanoparticles for targeted hepatocellular carcinoma therapy.Chinese Journal of Applied Chemistry, 37(1), 69-79, 2020.(IF: 6.000)

69. F. Vohidov, L. Milling, Q. Chen, W. Zhang, S. Bhagchandani, H. Nguyen, D. Irvine^*, J. Johnson^*. ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy.Chemical Science, 11, 5974, 2020.(IF: 9.969)

71. M. Qian, J. Xia, L. Zhang, Q. Chen, J. Guo, H. Cui, Y.S. Kafuti, J. Wang^*, X. Peng^*. Rationally modifying the dicyanoisophorone fluorophore for sensing cysteine in living cells and mice.Sensors and Actuators B: Chemical, 321, 1284411, 2020.(IF: 9.221)

72. T. A. Tockary, K. Osada^*, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka^*. Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers.Macromolecules, 46, 16, 6585, 2013.(IF: 6.057)

73. J. He, Z. Mou, Y. Tian, Y. Zhang, T. Guan, Q. Chen, L. Chen. Polymeric RNAi tailored with appreciable transcellular trafficking functions for potential suppression of parathyroid hormone production.Bioconjugate Chemistry, 32, 909-915, 2021.(IF: 6.069)

74. M. Qian, L. Zhang, Z. Pu, C. Zhang, Q. Chen, X. Sui, X. Han, S. Zeng, H. Cui, J. Wang, A mitochondria-targeting and polarity-sensitive fluorescent probe for cancer diagnosis.Sensors and Actuators B: Chemical, 344, 130261, 2021.(IF: 9.221)

75. H.V.T. Nguyen, Y. Jiang, S. Mohapatra, W. Wang, J.C. Barnes, N.J. Oldenhuis, K. Chen, S. Axelrod, Z. Huang, Q. Chen, M.R. Golder, K. Young, D. Suvlu, Y. Shen, A.P. Willard, M.J.A. Hore, R. Gómez-Bombarelli, J.A. Johnson^*. Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties.Nature Chemistry, 14, 85-93, 2022.(IF: 24.274)

76. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka^*. Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression.Biomacromolecules, 16, 2664, 2015.(IF: 6.978)

77. Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang^*. Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate.European Polymer Journal, 72, 222, 2015.(IF: 5.546)

78. F. Pittella, K. Miyata^*, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka^*. Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.Journal of Controlled Release, 161, 3, 868, 2012.(IF: 11.407)

79. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka^*. PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses.Molecular Therapy, 20, 6, 1196, 2012.(IF: 12.910)

80. A. Dirisala, K. Osada^*, Q. Chen, T.A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka^*. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.Biomaterials, 35, 20, 5359, 2014.(IF: 15.304)

81. X. Yang, W. Li, Q. Chen, M. Li, R. Qi^*. Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment.Nanomedicine: Nanotechnology, Biology and Medicine, 13, 287, 2016.(IF: 6.458)

82. X. Yang, Y. Yu, X. Huang, Q. Chen, H. Wu, R. Wang, R. Qi, R. Miao, Y. Qiu^*. Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance.Materials Science & Engineering C, 96, 96-104, 2019.(IF: 8.457)

83. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao^*. Dual functionalized amino poly (glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity.Journal of Materials Chemistry B, 3, 6911, 2015.(IF: 7.571)

84. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka^*. Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression.Biomacromolecules, 18, 36, 2017.(IF: 6.978)

85. J. He, Z. Mou, Y. Tian, L. Yu, T. Guan, Q. Chen, L. Chen*. Enclosure of siRNA in alternately hydrophilic-hydrophobic double layered nanoarchitectures for promoted RNAi.ACS Applied Polymer Materials, 4(4), 2262-2268, 2022.(IF: 4.855)

86. F. Wang, L. Wen, J. Liu, W. Peng, Q. Chen, H. Chen, B. Song, Y. Guo, P. Mi^*. Albumin nanocomposites with MnO₂/Gd₂O₃motifs for precise MR imaging of acute myocardial infarction in rabbit models.Biomaterials, 230, 119614, 2020.(IF: 15.304)

87. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao^*. Construction of stable polymeric vesicles based on azobenzene and β-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery.Chemical Communications, 51, 4715, 2015.(IF: 6.065)

88. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka^*. Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness.Small, 12, 1193, 2016.(IF: 15.177)

89. X. Yan, F. Ma, Q. Chem, X. Gou, X. Li, L. Zhang, H. Gao^*. Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum.Chemical Engineering Journal, 450, 137605, 2022.(IF: 16.744)

90.S. Zeng, Q. Chen, H. Li^*, J. Wang^*, J. Yoon^*. Construction of rhodamine-based AIE photosensitizer hydrogel with clinical potential for selective ablation of drug-resistant gram-positive bacteria in vivo. Advanced Healthcare Materials, 2022.(IF: 11.092)

91. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao^*. Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition.Journal of Materials Chemistry B, 4, 6350, 2016.(IF: 7.571)

92. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao^*. Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems.Journal of Materials Chemistry B, 5, 8322, 2017.(IF: 7.571)

93. Z. Lu, S. Zhang, J. Sheng, P. Gao, Q. Chen, Z. Peng, S. Wu^*, J. Ye^*. Rapid crystallization of amorphous silicon films utilizing Ar-H₂mesoplasma, annealing.Journal of Crystal Growth, 486, 142, 2018.(IF: 1.830)

94. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye^*. Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating.Energy Storage Materials, 11, 47-56, 2018.(IF: 20.831)

95. X. Liu, S. Zeng, M. Zhang, M. Jiang, J. Wang, P. Shuanguang, Y. Yu, Q. Chen, X. Peng, J. Yoon, H. Li. Monitoring mitochondrial nitroreductase activity in tumors and hind limb ischemic mice using a novel activatable NIR fluorescent probe.Chemical Communications, 2022.

授权专利（发明专利）：
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2003.9 -- 2007.6
开云平台首页 材料物理 学士

2010.10 -- 2013.9
东京大学 材料工学 博士

2008.10 -- 2010.9
东京大学 材料工学 硕士

2007.9 -- 2008.6
开云平台首页 材料物理 学士

2010.10 -- 2013.9
东京大学 材料工程 博士

2008.10 -- 2010.9
东京大学 材料工程 工学硕士

2017.7 -- 至今

开云平台首页 化工与环境生命学部特聘研究员

2015.4 -- 2017.3

麻省理工学院博士后

2013.11 -- 2015.3

东京大学博士后

2015.4 -- 2017.3

麻省理工学院化学系&癌症研究中心博士后研究员Completed

^-^基因药物递送系统的开发和应用：通过设计合成安全高效的基因递送功能分子，构建了包载DNA的纳米输运载体，通过对DNA凝缩理论的系统和深入研究，实现了对包载凝缩DNA纳米运载体的尺寸、形状和形状的精准控制，在病灶部位实现了持续高效的表达药用蛋白。

^-^克服血脑屏障的高渗透药物递送系统：针对脑退化疾病（阿尔海默病、帕金森病等）开发高效通透血脑屏障（BBB）的药物递送系统，实现靶向输送药物到神经元细胞或胶质细胞。

^-^肿瘤高靶向性、高渗透性纳米药物递送系统的研究：构建多功能、环境响应型、靶向性、智能化的聚合物纳米药物递送系统，通过对聚合物高分子的分子结构及其组装的纳米精准控制，实现对各类恶性肿瘤实现高效的治疗效果。

^-^具有响应性，功能性的生物水凝胶：针对人类重大慢性病（如眼科疾病：白内障，葡萄糖膜炎等疾病）以及人类重大疾病（原发或复发性恶性癌症等）开发的的高度可控的模块化介入型的纳米药物缓释体技术。