Qixian Chen is thrilled to serve as principal investigator (professor) in School of Life Science and Biotechnology, Dalian University of Technology, in attempt to challenge the cutting-edge technology of nanomedicine.

Education Background:

Oct 2010 – Sep 2013 The University of Tokyo, PhD, Materials Engineering Tokyo, Japan

Oct 2008 – Sep 2010 The University of Tokyo, Master Degree of Engineering, Materials Engineering Tokyo, Japan

Sep 2003 – Jun 2008 Dalian University of Technology, Bachelor of Science & Art, Materials Science and Technology & English Dalian, China

Research Experience:

Apr 2015 – Mar 2017 Joint Research Scientist, i) Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA, USA; ii) Massachusetts Institute of Technology, Koch Institute of Integrative Cancer Research Cambridge, Cambridge, MA, USA; iii) Massachusetts General Hospital, Boston, MA, USA

Nov 2013 – Mar 2015 Project Researcher, The University of Tokyo, Faculty & Graduate School of Engineering, Tokyo, Japan

Journal publications:

First authorship or corresponding authorship:

1. S. Chen^#, Q. Chen^#, Q. Li, J. An, P. Sun, J. Ma, H. Gao^*, Biodegradable synthetic antimicrobial with aggregation induced emissive luminogens for temporal antibacterial activity and facile bacteria detection. Chemistry of Materials, 30, 1782, 2018.
2. Q. Chen, K. Osada*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka^*, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials, 33, 18, 4722, 2012.
3. Q. Chen, K. Osada*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka^*, Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials, 113, 253, 2016.
4. Z. Ge^#, Q. Chen^#, K. Osada*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka^*, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials, 35, 10, 3416, 2014.
5. Q. Chen^#,*, R. Qi^#, X. Chen, H. Xiao, W. Dong^*, Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression. ACS Applied Materials & Interfaces, 8, 24404, 2016.
6. Q. Chen^#,*, R. Qi^#, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong^*, A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors. Molecular Therapy, 25(1), 92, 2017.
7. J. Li^#, Q. Chen^#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka^*, Z. Ge^*, Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery. Journal of Controlled Release, 209, 77, 2015.
8. X. Han^#, Q. Chen^#, H. Lu, J. Ma, H. Gao^*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative. ACS Applied Materials & Interfaces, 7, 28494, 2015.
9. X. Han^#, Q. Chen^#, W. Lu, G. Wu, J. Ma, H. Gao^*, Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form. Chemical Communications, 52, 3907, 2016.
10. T. Wang^#, Q. Chen^#, W. Li, G. Wu, J. Ma, H. Gao^*, Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing. Bioconjugate Chemistry, 27, 1949, 2016.
11. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen^*, H. Gao^*, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Applied Materials & Interfaces, 7, 23760, 2015.
12. Y. Li, J. Li, B. Chen, Q. Chen^*, G. Zhang, Z. Ge^*, S. Liu, Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection. Biomacromolecules, 15, 8, 2914, 2014.
13. J. Li, Y. Han, Q. Chen^*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge^*, S. Liu, Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin. Journal of Materials Chemistry B, 2, 13, 1813, 2014.
14. D. Liu^#, Q. Chen^#, Y. Long, J. Ma, H. Gao^*, A thermo-responsive polyurethane organogel for norfloxacin delivery. Polymer Chemistry, 9, 228, 2018.

15. X. Yang, Q. Chen^*, J. Yang, S. Wu, J. Liu, Z. Li, D. Liu, X. Chen, Y. Qiu*, Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness. ACS Applied Materials & Interfaces, 9(50), 44045-44052, 2017.
16. Z. Jiang, Q. Chen^*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao^*, Polyplex micelle with pH-responsive PEG detachment and functional tetraphenylene incorporation to promote systemic gene expression. Bioconjugate Chemistry, 28 (11), 2849-2858, 2017.
17. J. Yang, R. Liang, Y. Chen^*, C. Zhang, R. Zhang, X. Wang, R. Kang, Q. Chen^*, Using a self-assemblable nucleating agent to tailor crystallization behavior, crystal morphology, polymorphic crystalline structure, and biodegradability of poly(1,4-butylene adipate). Industrial & Engineering Chemistry Research, 56(28), 7910-7919, 2017.
18. J. Yang^*, X. Wang, R.Liang, R. Kong, Y. Sun, J. Tang, L. Li, L. Xue, Q. Chen^*, Polymorphism, thermal stability and biodegradation of poly(1,4-butylene adipate) manipulated by a benzene-1,3,5-tricarboxamide-based nucleating agent. Journal of Materials Science, 53, 10569-10581, 2018.
19. Q. Chen, K. Osada^*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka^*, A tadpole-shaped genecarrier with distinct phase segregation in ternary polymeric micelle. Soft Matter, 11, 14, 2718, 2015.
20. X. Chen^*, H. Gu, J. Yang, S. Wu, J. Liu, X. Yang, Q. Chen^*, Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles. ACS Applied Materials & Interfaces,9, 8455-8459, 2017.

21. Y. Huang^#, Q. Chen^#, H. Lu, J. An, H. Zhu, X. Yan, W. Li, H. Gao^*, Near-infrared AIEgen-functionalized and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert spatiotemporal responsibility for promoted gene delivery. Journal of Materials Chemistry B,6, 6660-6666, 2018.

22. J. Xia, J. Wang, X. Wang, M. Qian, L. Zhang, Q. Chen^*, Ultrasound-responsive nanoparticulate for selective amplification of chemotherapeutic potency for ablation of solid tumors. Bioconjugate Chemistry, 29(10), 3467-3475, 2018.

23. H. Zhu, J. An, C. Pang, S. Chen, W. Li, J. Liu, Q. Chen^*, H. Gao^*, A multifunctional polymeric gene delivery system for circumvent biological barriers. Journal of Materials Chemistry B, 7, 384-392, 2019.

24. S. Chen^#, Q. Chen^#, S. Dong, J. Ma, Y. Yang, L. Chen^*, H. Gao^*, Polymerbrush decorated MOF nanoparticles loaded with AIEgens, anticancer drug, and supramolecular glue for regulating and in situ observing DOX release. Macromolecular Bioscience, 18(12), 1800317, 2018.

25. P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu, Q. Chen^*, Transcellular delivery of messenger RNA payloads by cationic supramolecular MOF platform. Chemical Communications, 54, 11304-11307, 2018.

26.J. Wang, Y. Xia, H. Liu, J. Xia, M. Qian, L. Zhang, L. Chen, Q. Chen^*,Poly(lactobionamidoethyl methacrylate)-based copolymer with ultrasound-labile motif in manufacture of drug delivery nanoparticulates for augmented efficacy to hepatocellular carcinoma. Journal of Materials Chemistry B,551, 1-9, 2019.

27.W. Wang^#, S. Wu^#, J Wang, Z. Li, H. Cui, S. Lin, J. Zhu, Q. Chen^*,Intracellular superoxide dismutase delivery vehicles constructed from dendritic MOF and charge reversible protein derivatives. Chemical Science,10, 4476, 2019.

28. Near-infrared theranostic saponin nano-assembly based on fluorescence resonance energy transfer of AIEgen and photon upconversion nanoparticles. Chemical Communications, 2019.

29. Spatiotemporal controlled drug release artifice constructed from nitrophenyl-engaged photo-responsive amphiphiles. Journal of Colloid and Interface Science, 2019.

30. Mitochondria-targeted near-Infrared photosensitizer based on energy transfer of upconversion nanoparticle and its complementary photodynamic chlorin e6. Chemistry of Materials, 2019.

Other co-authorship：
31. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen,M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka^*, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nature Nanotechnology, 6, 12, 815, 2011.

32. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka^*, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Molecular Therapy, 20, 6, 1196, 2012.
33. F. Pittella, K. Miyata^*, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka^*, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. Journal of Controlled Release, 161, 3, 868, 2012.
34. T. A. Tockary, K. Osada^*, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka^*, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules, 46, 16, 6585, 2013.
35. A. Dirisala, K. Osada^*, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka*, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials, 35, 20, 5359, 2014.
36. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka^*, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression. Biomacromolecules, 16, 2664, 2015.
37. Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang^*, Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate. European Polymer Journal, 72, 222, 2015.
38. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao^*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery. Chemical Communications, 51, 4715, 2015.
39. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka^*, Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 12, 1193, 2016.
40. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge^*, Self-sufficing H₂O₂-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy. Journal of Controlled Release, 225, 64, 2016.
41. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen^*, Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy. Biomaterials, 100, 118, 2016.
42. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao^*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016.
43. X. Yang, W. Li, Q. Chen, M. Li, R. Qi^*, Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment. Nanomedicine: Nanotechnology, Biology and Medicine, 13, 287, 2016.
44. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka^*, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression. Biomacromolecules, 18, 36, 2017.
45. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems. Journal of Materials Chemistry B, 5, 8322, 2017.
46. R. Qi, Y. Wang, P. Bruno, H. Xiao, Y. Yu, T. Li, S. Lauffer, W. Wei, Q. Chen, X. Kang, H. Song, X. Yang, X. Huang, A. Detappe, U. Matulonis, D. Pépin, M. Hemann, M. Birrer, P. Ghoroghchian^*. Nanoparticle-conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer. Nature Communications, 8(1), 2166, 2017.
47. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka^*, Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity. Chemical Communications, 51, 15, 3158, 2015.

48. X. Yang, Y. Yu, X. Huang, Q. Chen, H. Wu, R. Wang, R. Qi, R. Miao,Y. Qiu^*, Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance. Materials Science & Engineering C, 96, 96-104, 2019.
49. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao^*, Dual functionalized amino poly (glycerol methacrylate) with guanidine and schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. Journal of Materials Chemistry B, 3, 6911, 2015.
50. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka^*, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. Journal of Controlled Release, 155, 2, 296, 2011.
51. Z. Lu, S. Zhang, J. Sheng, P. Gao, Q. Chen, Z. Peng, S. Wu^*, J. Ye^*, Rapid crystallization of amorphous silicon films utilizing Ar-H₂mesoplasma, annealing. Journal of Crystal Growth, 486, 142, 2018.

52. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye^*, Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating. Energy Storage Materials, 11, 47-56, 2018.

53. H. V.-T. Nguyen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D. Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson^*, Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors. ACS Central Science, 3, 800-811, 2017.

54. K. Itaka, S. Uchida^*, Q. Chen, T. Ishii, K. Osada, K. Kataoka^*, Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses. Huamn Gene Therapy, 10, 22, 88, 2011.

55. X. Yan, Q. Chen, J. An. D. Liu, Y. Huang, R. Yang, W. Li, L. Chen, H. Gao^*, Hyaluronic acid/PEGlated amphiphilic nanoparticulates for pursuit of selective intracellular doxorubicin release. Journal of Materials Chemistry B, 7, 95-102, 2019.

56. Efficient and controllable growth of vertically oriented graphene nanosheets by mesoplasma chemical vapor deposition. Carbon, 2018.

57. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang^*, Fabrication and physical properties of poly(epsilon-caprolactone)/modified graphene nanocomposite. Macromolecular Materials and Engineering, 302(3), 2016.

58. Albumin nanocomposites with MnO₂/Gd₂O₃motifs for precise MR imaging of acute myocardial infarction in rabbit models, 2019.

59. Z. Li, Q. Chen, Y. Qi, Z. Liu, T. Hao, X. Sun, M. Qiao, X. Ma, T. Xu, X. Zhao, C. Yang, D. Chen^*, Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-vitamin E Succinate for reversing tumor multidrug resistance. Biomacromolecules, 19, 2595-2609, 2018.

60. Ternary polymeric anti-VEGF therapeutics with hyaluronic acid surface motif for tumor targeted anti-angiogenesis of primary and metastatic tumors, 2019.

Patents：
1. US9314529B2 Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and the method for nucleic acid delivery

2. DK2591792T3 Sammensætning til nukleinsyre-afgivelse, bæremiddel-sammensætning, pharmaceutisk sammensætning med sammensætning til nukleinsyre-afgivelse eller bæremiddel-sammensætning og fremgangsmåde til nukleinsyre-afgivelse

3. JP5826174B2 核酸送達用組 成物及び担体組成物、それを用いた医薬組成物、並びに核酸送達方法

4.EP2591792B1 Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid

5. CN102971002A 核酸递送用组 合物及载体组合物、使用其的药物组合物以及核酸递送方法
6. CA2804815C Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and method for nucleic acid delivery
7. US62404098 Bottlebrush copolymers and uses thereof
8. CN201610334823.7 纳米药物存储器、其制备方法及其应用
9. CN207107734 一种复合蛋白质脂质体纳米制剂
10. CN201710561380 一种金属有机骨架聚阳离子衍生物及其制备方法和应用