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Team Introduction

化学家常常自嘲为厨子。烟火，佐料，每一道菜，可以管饱，也可以只负责貌美如花。课题组自2004年至今，在化学领域旗舰杂志Angew Chem Int Ed.发表封面论文，在药理学顶级期刊和药物化学最具影响力的期刊发表20余篇研究论文。我们的研究，是化学连接生命科学的玻璃天桥，风光无限，惊险刺激。我们是没有菜谱的厨子...

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Team Member

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Ting Song

王紫千

张弘

王航

蒋茂军

袁琳杰

刘晶晶

李鑫

殷方奎

王钰莹

王兴钰

黎怡同

王哲明

胡治远

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辽宁省科学技术奖

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Paper

Research Direction

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王紫千.Targeting the allosteric pathway that interconnect the core-functional scaffold and the distal phosphorylation sites for specific dephosphorylation of Bcl-2..[J].Journal of medicinal chemistry,2021,63(1111):13733-13744. Zhang Zhichao.A “three-in-one” multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ..[J].ChemBioChem,2021,22326-329. 张志超.Affinity-based probe reveal Bim negatively regulates the chaperone functions of Hsp70, a non-Bcl-2 BH3 receptor...[A].2019,(13 Supplement): 792754-. Zhang Zhichao.DNA Double Helix Unwinding Triggers Transcription Block-Dependent Apoptosis: A Semiquantitative Probe of the Response of ATM, RNAPII, and p53 to Two DNA Intercalators.[J].CHEMICAL RESEARCH IN TOXICOLOGY,2021,22(3):483-491. Zhang, Han.Qiu, Jieshan,Tian, Dongxu,Zhao, Zongbin,Liu, Xuguang,Hou, Ya-Nan,Tang, Yujiao,Liang, Jingjing,Zhang, Zhichao,Wang, Xuzhen.Cobalt nitride nanoparticles embedded in porous carbon nanosheet arrays propelling polysulfides conversion for highly stable lithium-sulfur batteries.[J].ENERGY STORAGE MATERIALS,2019,21210-218. 郭宗伟.宋婷,薛祖光,刘朋,张民行,张肖冬,张志超.Using CETSA assay and a mathematical mode lto reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1.[J].European Journal of Pharmaceutical Sciences,2019,142(15): Zhu Junjie.Wang Ziqian,Guo Zongwei,Zhang Xiaodong,Song Ting,Guo Yafei,Ji Tong,Zhang Zhichao.Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors.[J].Archiv der Pharmazie,2020,353(5):e2000005.

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