Primarily based on X-ray crystallographic methods,

we use a multi-disciplinary approach to probe the functional roles of large

molecular assemblies. Three-dimensional structures of biological molecules

provide us with a wealth of atomic details along specific functional pathways

that are further analyzed by biochemical, genetic, and theoretical methods. Our

goal is to be able to understand, and ultimately to predict, the physical and

chemical principles governing molecular recognition and catalytic processes of

the assemblies.

In

thisminiworkshop,

I will teach the fundamental principle of X-ray crystallography starting from

the theory of Fourier Transformation and ending with some practical tips of

solving structures by X-ray crystallography. Students will learn key

terminologies and the physical and mathematical basis behind them.