李广哲，药学博士，教授，硕士生导师；

中国化学会、日本化学会、日本药学会、日本癌分子靶向治疗学会会员；

邮箱：liguangzhe@dlut.edu.cn

【个人经历】

• 2002.09－2006.07开云平台首页 制药工程，工学学士

• 2006.09－2009.07开云平台首页 药物工程，理学硕士

• 2009.10－2013.03日本东北大学药学研究科，药学博士

• 2013.04－2014.04日本东北大学药学研究科，助教

• 2014.05－2015.09东京工业大学化学生命开云体育nba 所，助教

• 2015.12－2021.12　开云平台首页 化工学院药学系，副教授

• 2022.01－至今　　开云平台首页 化工学院药学系，教授

• 2016.10－至今　　开云平台首页 化工学院药学系教工党支部书记兼副系主任

【研究内容】

面向人民生命健康，围绕恶性肿瘤等重大疾病治疗的新靶点、新药物和新方法开展应用基础研究：

1.分子靶向抗肿瘤药物的研究：HIF-1抑制剂、热休克蛋白HSP90、HSP60抑制剂等；

2.用于光动力、声动力治疗的光敏剂、声敏剂的设计与开发；

3. BNCT治疗中含硼药物的设计与开发；

4.药物活性分子导向的绿色有机合成新方法的开发。

【代表性研究成果】

18.Wang, L.;Li, G.*; Cao, L.; Shao, K.; Li, Y.; Zhang, X.; Zhao, J.; Zhao, W.* A novel water-soluble chlorin-based photosensitizer for low-fluence photodynamic therapy.ACS Pharmacol. Transl. Sci.,2022,2, 110-117.

17.Li, G.*; Yu, G.;Wang, C.;Morita,T.; Zhang, X.;Nakamura, H.*Copper(i)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with phosphites.Org. Biomol. Chem.,2022,20, 113-116.

16.Wang, L.;Li, G.*; Cao, L.; Dong, Y.; Wang, Y.; Wang, S.; Li, Y.; Guo, X.; Zhang, Y.; Sun, F.;Du,X.;Su, J.;Li, Q.;Peng X.; Shao, K.*; Zhao, W.*An Ultrasound-Driven Immune Boosting Molecular Machine for Systemic Tumor Suppression.Sci. Adv.,2021,7, eabj4796.

15.Li, G.*; Shao, Y.; Pan Y.; Li, Y.; Wang, Y.; Wang, L.; Wang, X.; Shao, K.; Wang, S.; Liu, N.; Zhang, J.; Zhao, W.; Nakamura, H. Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy.Bioorg. Med. Chem. Lett.,2021,50, 128338.

14.Wang, S.; Wang, X.; Shao, Y.; Shao, K.; Wang, Y.; Guo, X.; Dong, H.; Zhao, W.; Li, Y.;Li, G.*Synthesis and evaluation of 3-(phenylethynyl)-1,1′-biphenyl-2-carboxylate derivatives as new HIF-1 inhibitors.Bioorg. Chem.,2021,116, 105298.

13.Li, G.*; Wang, C.; Li, Y.; Shao, K.; Yu, G.; Wang, S.; Guo, X.; Zhao, W.; Nakamura, H. Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with diverse carbon pronucleophiles: facile access to functionalized tetrahydroquinolines.Chem. Commun.,2020, 7333-7336.

12.Dong, Y.;Li, G.*; Wang, L.; Cao, L.; Li, Y.; Zhao, W.*Anti-tumor evaluation of a novel methoxyphenyl substituted chlorin photosensitizer for photodynamic therapy.J. Photoch. Photobio. B,2020,211, 112015.

11.Li, G.*; Dong, H.; Ma, Y.; Shao, K.; Li, Y.; Wu, X.; Wang, S.; Shao, Y.; Zhao, W. Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors.Bioorg. Med. Chem. Lett.,2019, 29, 2327-2331.

10.Wang, S.; Liu, L.; Guo, X.;Li, G.*; Wang, X.; Dong, H.; Li, Y.; Zhao, W. Synthesis of novel natural product-like diaryl acetylenes as hypoxia inducible factor-1 inhibitors and antiproliferative agents.RSC Adv.,2019,9, 13878-13886.

9.Li, Y.;Li, G.*; Dong, Y.; Ma, X.; Dong, H.; Wu, Q.; Zhao, W.*Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays.Bioorg. Chem.,2019, 85, 357-363.

8.Li, G.;Shao, K.; SokkeUmeshappa C. Recent progress in blood-brain barrier transportation research. In : Gao H, Gao X(Eds.),Brain Targeted Drug Delivery System, Elsevier,2019, 33-51.

7.Li, G.;Ban, H.; Nakamura, H. Design of Carborane‐Based Hypoxia‐Inducible Factor Inhibitors. In: Evamarie H, Clara V T (Eds.),Boron‐Based Compounds: Potential and Emerging Applications in Medicine, Wiley,2018, 35-59.

6.Li, G.; Nakamura, H.*Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling ofN-Propargylanilines with Indoles.Angew. Chem. Int. Ed.,2016,55, 6758-6761.

5.Li, G.; Azuma, S.; Sato, S.; Minegishi, H.; Nakamura, H.*ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity.Bioorg. Med. Chem. Lett.,2015,25, 2624-2628.

4.Li, G.; Azuma, S.; Minegishi, H.; Nakamura, H. Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity.J. Organomet. Chem.,2015, 798, 189-195.

3.Li, G.; Arisawa, M.; Yamaguchi, M.* Rhodium-catalyzed synthesis of unsymmetrical di(aryl/heteroaryl) methanes using aryl/heteroarylmethyl ketones via CO-C bond cleavage.Chem. Commun.,2014,50, 4328-4330.

2.Li, G.; Arisawa, M.; Yamaguchi, M.* Rhodium-Catalyzed Synthesis and Reactions ofN-Acylphthalimides.Asian J. Org. Chem.,2013,2, 983-988.

1.Arisawa, M.*;Li, G.; Yamaguchi, M.* Rhodium-catalyzed synthesis of 2,3-diaryl-1,4-diketones via oxidative coupling of benzyl ketones using α-thioketone oxidizing reagent.Tetrahedron Lett.,2013,54, 1298-1301.

【个人奖励】

• 2016年，入选开云平台首页 “星海学者”人才培育计划“星海骨干”

• 2018年，入选开云平台首页 “星海学者”人才培育计划“星海优青”

• 2016年，开云平台首页 青年教师讲课竞赛二等奖

• 2019年，全国高等学校药学类专业青年教师教学能力大赛 一等奖

• 2019年，全国高等学校药学类专业青年教师微课教学大赛 特等奖

2022年招收药学（学硕），药物工程（学硕），生物与医药（专硕）硕士研究生，

欢迎制药工程、药学、化学、化工、生物工程、生物学等相关专业的考生报考！